Cureline collects biospecimens from patients with all types of hematologic malignancies (ALL, AML, CLL, CML, MM, MDS, etc.) in the chronic and crisis stages of the disease. Cancer blood, bone marrow aspirate and bone marrow Human Tumor Tissues">trephine biopsy specimens obtained from these patients are used for cellular and molecular analyses for drug discovery pre clinical research drug safely evaluation, biomarker development and pre-selection of indications for clinical trials.

Biosample Collection and Research Services
Specimen Format and Sets
Recent Projects
To inquire about the current availability of hematologic malignancies specimens in our tissue bank or to investigate your custom project feasibility, contact our office or send us an inquiry via email.
 
Biosample Collection and Research Services
Cureline team works closely with principal investigators and project managers on developing custom protocols, conducting feasibility studies and managing biosample acquisition projects.
 
Standard acquisition protocols for the collection of clinically-defined hematologic malignancies specimens include:
 
  • Collection of fresh cancer blood and preparation of human viable blood cells or frozen PBMC pellets
  • Collection of cancer bone marrow aspirate and preparation of viable BMMC or frozen BMMC pellets
  • Preparation of cancer bone marrow FFPE ( Human Tumor Tissues">trephine biopsy FFPE and paraffin-embedded BMMC pellets)
Standard Specimen Format and Sets

Leukemia / Lymphoma Specimens
  • Cancer PBMC, snap-frozen pellet
  • Viable PBMC from cancer blood
  • Marker-specific PBMC (CD19 , etc.)
  • Matching cancer serum, cancer plasma, cancer blood
  • Bone marrow aspirate, snap-frozen
  • Bone marrow Human Tumor Tissues">trephine biopsy snap-frozen
  • Bone marrow FFPE from threphine biopsy
  • Bone marrow FFPE from cancer BMMC
Multiple Myeloma / MDS Specimens
  • Bone marrow aspirate, snap-frozen
  • Bone marrow Human Tumor Tissues">trephine biopsy snap-frozen
  • Viable BMMC from cancer bone marrow
  • Cancer BMMC, snap-frozen
  • Marker-specific BMMC (CD138 , etc.)
  • Matching cancer serum, cancer plasma
  • Bone marrow FFPE from threphine biopsy
 


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Recent Projects

APPLICATION: Functional in vitro studies (signal transduction, apoptosis, drug sensitivity) using a new drug candidate.
Leukemia Specimens (CLL, CML, ALL, AML):

Isolation of PBMC from fresh blood using Ficoll-based procedure, and preparation of viable cells in DMSO-containing medium; Collection of matching cancer serum samples and extensive clinical information for each patient
Multiple Myeloma Specimens:
Isolation of CD138 cells from fresh bone marrow aspirate using magnetic beads and preparation of viable cells; Collection of matching cancer serum samples and extensive clinical information for each patient

APPLICATION: Target expression profiling (RNA, protein, IHC)
Chronic Lymphocytic Leukemia (CLL) Specimens:
Isolation of CD19 cells from fresh blood using magnetic beads and preparation of snap-frozen cell pellets; Collection of matching cancer serum samples and extensive clinical information for each patient
CLL and Multiple Myeloma Specimens:
Preparation of FFPE bone marrow Human Tumor Tissues">trephine biopsy specimens
Multiple Myeloma Specimens:

Preparation of FFPE blocks from isolated human bone marrow mononuclear cells (BMMC). Collection of matching cancer serum samples and extensive clinical information for each patient
Myelodysplastic Syndrome Specimens:
Preparation of viable BMMC, snap-frozen cell pellets and RNA. Collection of matching cancer serum samples and extensive clinical information for each patient

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