FFPE Blocks

Collection Protocol Specifications: 

A  piece of human tissue prepared by a certified medical pathologist is submerged in 10% neutral-buffered formalin for maximum of 24 hours and embedded in IHC-grade paraffin. The target FFPE specimen size is 0.5 x 1 x 1 cm, but it can vary significantly depending on the nature of the disease and tissue type. The fixation agent and the embedding media can be customized upon request.

Therapeutic Areas:

•   Oncology (Cancer Quadruplet tissue set, frozen serum/plasma, blood in special tubes)
•   Inflammation (synovial tissue, synovial fluid, matching blood, serum, plasma)
•   Neurological Diseases (postmortem brain tissue from patients with PD and AD)
•   Normal Tissues (4 - 12 hours postmortem and surgical collection)

To inquire about the current availability of specimens or to investigate your custom project feasibility, contact our office or send us an inquiry via email.


Recent Collections:

Cancer QUADRUPLET
Normal Human Brain Map
Normal Human Tissues
Archival FFPE Specimens
Breast Carcinoma

•     Cancer QUADRUPLET: 

•  Tumor tissue, snap-frozen (fresh-frozen, FF)

•  Adjacent normal tissue (ANT), snap-frozen

•  Tumor tissue, formalin-fixed paraffin-embedded (FFPE)

•  Adjacent normal tissue, FFPE
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•     Normal Human Brain Map
•  Nucleus Substantia nigra 

•  Nucleus Raphe

•  Ventral pole

•  Orbital gyrus

•  Cingulum bundle

•  Accumbens

•  Amygdala

•  Putamen

•  Nucleus caudate

•  Hippocampus		 •  Thalamus

•  Parietal cortex

•  Cerebellar vermis

•  Cerebellar hemisphere

•  Dorsolateral prefrontal cortex

•  Pituitary gland

•  Hypothalamus

•  Spinal cord (cross-section)

•  Peripheral Ganglia 
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•     Normal Human Tissues
•  Adrenal (Category II)

•  Bladder

•  Blood cells (PBMC)

•  Bone marrow (BM)

•  Breast

•  Cerebellum (Category II)

•  Cerebral cortex (Category II)

•  Colon (duodenum, colon, rectum)

•  Endothelium

•  Fallopian tube

•  Fat (omental, other)

•  GI tract (stomach, esophagus)

•  Heart (various parts)

•  Kidney (medulla and cortex)

•  Liver 

•  Lung (including bronchioles)  		 •  Lymph node (central)

•  Muscle (striated, others)

•  Ovary

•  Pancreas (Category II)

•  Parathyroid (Category III)

•  Pituitary (Category II)

•  Placenta 

•  Prostate

•  Skin

•  Spinal cord (cross-section)

•  Spleen

•  Testis

•  Thyroid (Category II)

•  Ureter

•  Uterus (cervix, endometrium)

 

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Archival FFPE Specimens:

Lymphoma: MALT subtype
Collection of FFPE specimens with t(11;18) q(21;21) translocation.
APPLICATION: Control for development of diagnostic Antibodies (IHC).

Breast cancer: Her-2 positive metastatic breast cancer
Collection of Her-2 positive tumor tissue and a metastatic lesion (FFPE blocks) from treatment-naive breast cancer patients. 
APPLICATION: Correlative target expression study.

Breast cancer: "aged" breast cancer FFPE blocks
Collection of FFPE tumor tissue procured at the same clinical center from past years.  
APPLICATION: Investigation of "aged" FFPE tissue suitability for a specific assay.

 Breast cancer: mutation-specific tumor FFPE blocks
Large-scale procurement of FFPE tumor tissues for selection of whose with mutated p53 gene.  
APPLICATION: diagnostic test development and validation.

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